Trained by Patients-on-a-Chip.
A radical new approach
to predict drug safety.
“Quris is applying a disruptive bio-AI approach that my colleagues and I have previously used with dramatic success: we have analyzed the human genome, discovering hundreds of novel microRNA genes, more than all the universities in the world combined!
At Quris, we are now applying this approach to revolutionize drug development: we use Patients-on-a-Chip to generate a massive proprietary dataset that is automated, highly predictive, and uses classification algorithms to train the machine learning model to better predict which drug candidates will safely work in humans.”
Isaac Bentwich, MD
Founder & CEO
Bio-AI Clinical Prediction Platform
Predicting which drug candidates will be safe and efficacious in humans is a formidable challenge. Traditional pre-clinical data, used or generated by other AI-pharma companies – lab, mice, genomics – is easily accessible, but very poorly predicts clinical safety and efficacy (remember that 89% of drugs fail in clinical trials, despite promising pre-clinical data!). Quris’ unique machine-learning approach using the Bio-AI Clinical Prediction Platform is radically different: By using a patented process to test known safe and unsafe drugs on miniaturized Patients-on-a-Chip with our automated, high-throughput system, data is generated, classified, and continuously re-trains the machine learning algorithm which is highly predictive of clinical safety and efficacy.
Our AI Chip-on-Chip platform (18 granted and pending patents) allows automated testing of thousands of drugs on miniaturized Patients-on-a-Chip, while next-generation nano-sensors allow for continuous monitoring of the responses from each miniaturized organ to these drugs. Our machine-learning classification algorithm is trained by the data continuously generated in this high-throughput system.
Leveraging the Genomic Diversity of Stem Cells
The ability to train the machine learning model on a single Patient-on-a-Chip is limited. Our Bio-AI Clinical Prediction Platform leverages powerful AI to train the system on hundreds of stem cell-derived Patients-on-a-Chip, which reflect an extremely broad genomic diversity. This is made possible through our exclusive collaboration with the New York Stem Cell Foundation, the world leader in stem-cell automation.
Our AI Chip on Chip platform is uniquely scalable. Successfully tackling the complexities of clinical prediction requires machine learning models to routinely run thousands, and eventually millions, of biological Patients-on-a-Chip experiments for AI training. Limitations of older organ-chip devices preclude the ability to run such experiments, however our patented platform is highly scalable and tightly integrated with the AI, enabling massive experiments at a small fraction of the cost.